39 results
Limited impact of a nudge comment in promoting de-escalation to first-generation cephalosporins in urinary tract infections
- Martin T. Brenneman, Sarah E. Moore, Matthew Song, Brian C. Bohn, Elena A. Swingler, Christopher W. Whitman, Alan D. Junkins, Ashley M. Wilde
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- Journal:
- Antimicrobial Stewardship & Healthcare Epidemiology / Volume 2 / Issue 1 / 2022
- Published online by Cambridge University Press:
- 26 September 2022, e160
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In this study, we evaluated the impact of a microbiology nudge on de-escalation to first-generation cephalosporins in hospitalized patients with urinary tract infections secondary to Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis isolates with minimum inhibitory concentrations (MICs) ≤ 16 µg/mL. De-escalation to first generation-cephalosporins was uncommon at MICs = 4–16 µg/mL.
Characterization of a hospital-based gastroenteritis outbreak caused by GII.6 norovirus in Jinshan, China
- X. F. Zhang, J. R. Chen, C. L. Song, D. J. Xie, M. Tan, L. Wang, M. M. Koroma, Y. Z. Hou, Z. P. Dong, J. R. Yu, W. T. Duan, D. D. Zhao, J. R. Du, L. Zhu, Y. C. Dai
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- Journal:
- Epidemiology & Infection / Volume 148 / 2020
- Published online by Cambridge University Press:
- 09 December 2020, e289
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An acute gastroenteritis (AGE) outbreak caused by a norovirus occurred at a hospital in Shanghai, China, was studied for molecular epidemiology, host susceptibility and serological roles. Rectal and environmental swabs, paired serum samples and saliva specimens were collected. Pathogens were detected by real-time polymerase chain reaction and DNA sequencing. Histo-blood group antigens (HBGA) phenotypes of saliva samples and their binding to norovirus protruding proteins were determined by enzyme-linked immunosorbent assay. The HBGA-binding interfaces and the surrounding region were analysed by the MegAlign program of DNAstar 7.1. Twenty-seven individuals in two care units were attacked with AGE at attack rates of 9.02 and 11.68%. Eighteen (78.2%) symptomatic and five (38.4%) asymptomatic individuals were GII.6/b norovirus positive. Saliva-based HBGA phenotyping showed that all symptomatic and asymptomatic cases belonged to A, B, AB or O secretors. Only four (16.7%) out of the 24 tested serum samples showed low blockade activity against HBGA-norovirus binding at the acute phase, whereas 11 (45.8%) samples at the convalescence stage showed seroconversion of such blockade. Specific blockade antibody in the population played an essential role in this norovirus epidemic. A wide HBGA-binding spectrum of GII.6 supports a need for continuous health attention and surveillance in different settings.
The MeerKAT telescope as a pulsar facility: System verification and early science results from MeerTime
- M. Bailes, A. Jameson, F. Abbate, E. D. Barr, N. D. R. Bhat, L. Bondonneau, M. Burgay, S. J. Buchner, F. Camilo, D. J. Champion, I. Cognard, P. B. Demorest, P. C. C. Freire, T. Gautam, M. Geyer, J.-M. Griessmeier, L. Guillemot, H. Hu, F. Jankowski, S. Johnston, A. Karastergiou, R. Karuppusamy, D. Kaur, M. J. Keith, M. Kramer, J. van Leeuwen, M. E. Lower, Y. Maan, M. A. McLaughlin, B. W. Meyers, S. Osłowski, L. S. Oswald, A. Parthasarathy, T. Pennucci, B. Posselt, A. Possenti, S. M. Ransom, D. J. Reardon, A. Ridolfi, C. T. G. Schollar, M. Serylak, G. Shaifullah, M. Shamohammadi, R. M. Shannon, C. Sobey, X. Song, R. Spiewak, I. H. Stairs, B. W. Stappers, W. van Straten, A. Szary, G. Theureau, V. Venkatraman Krishnan, P. Weltevrede, N. Wex, T. D. Abbott, G. B. Adams, J. P. Burger, R. R. G. Gamatham, M. Gouws, D. M. Horn, B. Hugo, A. F. Joubert, J. R. Manley, K. McAlpine, S. S. Passmoor, A. Peens-Hough, Z. R Ramudzuli, A. Rust, S. Salie, L. C. Schwardt, R. Siebrits, G. Van Tonder, V. Van Tonder, M. G. Welz
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- Journal:
- Publications of the Astronomical Society of Australia / Volume 37 / 2020
- Published online by Cambridge University Press:
- 15 July 2020, e028
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We describe system verification tests and early science results from the pulsar processor (PTUSE) developed for the newly commissioned 64-dish SARAO MeerKAT radio telescope in South Africa. MeerKAT is a high-gain ( ${\sim}2.8\,\mbox{K Jy}^{-1}$ ) low-system temperature ( ${\sim}18\,\mbox{K at }20\,\mbox{cm}$ ) radio array that currently operates at 580–1 670 MHz and can produce tied-array beams suitable for pulsar observations. This paper presents results from the MeerTime Large Survey Project and commissioning tests with PTUSE. Highlights include observations of the double pulsar $\mbox{J}0737{-}3039\mbox{A}$ , pulse profiles from 34 millisecond pulsars (MSPs) from a single 2.5-h observation of the Globular cluster Terzan 5, the rotation measure of Ter5O, a 420-sigma giant pulse from the Large Magellanic Cloud pulsar PSR $\mbox{J}0540{-}6919$ , and nulling identified in the slow pulsar PSR J0633–2015. One of the key design specifications for MeerKAT was absolute timing errors of less than 5 ns using their novel precise time system. Our timing of two bright MSPs confirm that MeerKAT delivers exceptional timing. PSR $\mbox{J}2241{-}5236$ exhibits a jitter limit of $<4\,\mbox{ns h}^{-1}$ whilst timing of PSR $\mbox{J}1909{-}3744$ over almost 11 months yields an rms residual of 66 ns with only 4 min integrations. Our results confirm that the MeerKAT is an exceptional pulsar telescope. The array can be split into four separate sub-arrays to time over 1 000 pulsars per day and the future deployment of S-band (1 750–3 500 MHz) receivers will further enhance its capabilities.
Effects of nitrogen application and supplemental irrigation on canopy temperature and photosynthetic characteristics in winter wheat
- D. Q. Yang, W. H. Dong, Y. L. Luo, W. T. Song, T. Cai, Y. Li, Y. P. Yin, Z. L. Wang
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- Journal:
- The Journal of Agricultural Science / Volume 156 / Issue 1 / January 2018
- Published online by Cambridge University Press:
- 18 January 2018, pp. 13-23
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Nitrogen (N) application and irrigation to winter wheat may decrease leaf temperature and enhance photosynthesis: as a result, more photosynthates will be allocated to the grains, resulting in higher grain yields. To investigate this hypothesis, a 2-year field study was conducted with three levels of N fertilizer application (no fertilizer, N0; 240 kg N/ha, N1; 360 kg N/ha, N2) and two different water regimes (rainfed with no irrigation, R; irrigation at the over-wintering, stem elongation and grain filling stages, W). The results show that both N application and supplemental irrigation significantly increased grain yield with increases in both grain number/m2 and the 1000-grain weight, viz., WN2>WN1>WN0>RN2>RN1>RN0. In addition, application of N under both water regimes significantly increased flag leaf area, above-ground biomass and single stem productivity and decreased leaf temperature, which led to an increase in net photosynthesis rates and ribulose bisphosphate (RuBP) carboxylase activity. Moreover, analysis of the chlorophyll α fluorescence transient showed that N fertilizer application and supplemental irrigation significantly increased electron donor and acceptor performance of the photosystem II reaction centre.
Effect of urea fertilization on biomass yield, chemical composition, in vitro rumen digestibility and fermentation characteristics of forage oat straw in Tibet of China
- J. H. CUI, H. J. YANG, C. Q. YU, S. BAI, S. S. SONG, T. T. WU, W. SUN, X. M. SHAO, L. S. JIANG
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- Journal:
- The Journal of Agricultural Science / Volume 154 / Issue 5 / July 2016
- Published online by Cambridge University Press:
- 18 March 2016, pp. 914-927
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The present study investigated the effects of different levels of urea nitrogen (N) fertilizer on nutrient accumulation, in vitro rumen gas production and fermentation characteristics of forage oat straw (FOS) from oats (Avena sativa L. ‘Qinghai 444’) grown in the Tibet region of China. Fertilizer, applied at seeding (day 1), stem elongation (days 52–54) and heading (days 63–67), increased plant height and prolonged the maturity stage of the plant by 4–11 days compared with the non-fertilized control. Oat plants were harvested at maturity at the node 3–4 cm above ground, and then separated into grains and FOS. Both FOS and grain yields increased quadratically with increasing N fertilization, and their theoretical maximums occurred at the N fertilizing rates of 439 and 385 kg/ha, respectively. Increases in N fertilization did not affect the hemicellulose content of FOS, but substantially promoted the accumulation of crude protein, cellulose and lignin, resulting in a decrease in the energy content available for metabolism. A 72-h incubation of FOS with rumen fluids from lactating cows showed that increasing N resulted in FOS that showed a slower fermentation rate, decreased in vitro dry matter disappearance and lower cumulative gas production, but unchanged fermentation gas composition. Nitrogen fertilization increased the final pH in culture fluids and decreased the microbial volatile fatty acid (VFA) production. The molar proportions of acetate and propionate were not affected, but molar propionate proportion decreased linearly with increasing urea fertilization, and consequently, the ratio of lipogenic (e.g., acetate and butyrate)-to-glucogenic acids (propionate) tended to increase. In brief, increasing urea N fertilization promoted the growth of forage oats and increased the biomass yield as well as the crude protein and cellulose content of FOS. Considering the negative effect of increased lignin content on nutrient digestibility and total VFA production, the suggested range of urea N fertilization is 156–363 kg N/ha for forage oats planted in Tibet to retain the nutritive value of FOS in the rumen.
Primary tumour characteristics predict the invasiveness of lymph node metastases in papillary thyroid carcinoma patients
- H S Lee, C Park, S W Kim, J W Song, B K Chun, T J Park, J C Hong, K D Lee
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- Journal:
- The Journal of Laryngology & Otology / Volume 130 / Issue 3 / March 2016
- Published online by Cambridge University Press:
- 16 December 2015, pp. 302-308
- Print publication:
- March 2016
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Objective:
This study evaluated whether primary tumour characteristics are associated with specific features of metastatic lymph nodes in papillary thyroid carcinoma patients.
Method:A retrospective review of 411 patients with pathologically diagnosed cervical lymph node metastasis was conducted.
Results:A metastatic lymph node focus size of at least 2 mm was independently associated with a primary tumour size of at least 1 cm (hazard ratio 1.962) and with male sex (hazard ratio 1.947). A number of at least five lymph node metastases was independently associated with a primary tumour size of at least 1 cm (hazard ratio 2.863), extrathyroidal extension (hazard ratio 1.737) and male sex (hazard ratio 1.689). Extranodal extension was independently associated with a primary tumour size of at least 1 cm (hazard ratio 2.288), extrathyroidal extension (2.201) and male sex (hazard ratio 1.733).
Conclusion:Primary papillary thyroid carcinoma characteristics are related to the pathological features of lymph node metastases.
Prevalence of allergic rhinitis among elementary and middle school students in Changsha city and its impact on quality of life
- Y Song, M Wang, J Xie, W Li, X Zhang, T Wang, G Tan
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- Journal:
- The Journal of Laryngology & Otology / Volume 129 / Issue 11 / November 2015
- Published online by Cambridge University Press:
- 22 September 2015, pp. 1108-1114
- Print publication:
- November 2015
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Objectives:
To investigate the prevalence of allergic rhinitis among elementary and middle school students and examine its impact on their quality of life.
Methods:Stratified sampling and cluster sampling surveys were performed among 10–17-year-old students in Changsha city from June 2011 to April 2012.
Results:In the stratified sampling survey, the self-reported allergic rhinitis rate was 42.5 per cent. Further examination demonstrated that the average prevalence of allergic rhinitis was 19.4 per cent. The cluster sampling survey demonstrated that 214 of 814 students appeared to be atopic (26.3 per cent). The prevalence of allergic rhinitis and asthma was 17.2 and 2.1 per cent, respectively. In total, 71 atopic individuals (8.7 per cent) were without any symptoms of allergic disease. Further analysis showed that allergic rhinitis influenced the students' sleep, emotions and memory (p < 0.001).
Conclusion:The prevalence of allergic rhinitis was 15.8 –19.4 per cent, showing an increase with age. Allergic rhinitis affected students' sleep, emotions and memory.
Effect of urea fertilization on biomass yield, chemical composition, in vitro rumen digestibility and fermentation characteristics of straw of highland barley planted in Tibet
- J. H. CUI, H. J. YANG, C. Q. YU, S. BAI, T. T. WU, S. S. SONG, W. SUN, X. M. SHAO, L. S. JIANG
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- Journal:
- The Journal of Agricultural Science / Volume 154 / Issue 1 / January 2016
- Published online by Cambridge University Press:
- 20 August 2015, pp. 151-164
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A completely randomized experiment for planting highland barley in 36 field plots of the Lhasa Agricultural Experiment Station was applied to investigate the effect of urea nitrogen (N) fertilization levels of 0 (control), 156, 258, 363, 465 and 570 kg/ha on nutrient accumulation, in vitro rumen gas production and fermentation characteristics of highland barley straw (HBS). Each urea application was divided into three portions of 0.4, 0.3 and 0.3 and sequentially fertilized at seeding (growth stage (GS) 0), stem elongation (GS 32) and heading (GS 49), respectively. The maturity stage lasted 5–13 days longer in response to the urea N fertilization compared with the control. After removing grains, HBS biomass was harvested at maturity. The biomass yields of leaf, stem, straw and grain were increased quadratically with increasing urea N fertilization, and HBS and grain yields peaked at the estimated urea N fertilization levels of 385 and 428 kg/ha, respectively. The increase of urea N fertilization increased the accumulation of crude protein, cellulose and lignin, and decreased the content of ash and hemicellulose in HBS, resulting in a decrease of the energy content available to be metabolized. After incubating HBS for 72 h with rumen fluids from lactating cows, the urea N fertilization decreased in vitro dry matter disappearance and cumulative gas production, and slightly altered fermentation end-gas composition. Urea N fertilization decreased microbial volatile fatty acid production, but did not alter the ratio of lipogenic acetate and butyrate to glucogenic propionate. In a brief, the current urea N fertilization strategy promoted the growth of the highland barley and increased biomass yield, protein and cellulose accumulation of HBS. A urea N fertilization level ⩽385 kg/ha could be sufficient for growth of highland barley in Tibet without a consequent nutritive reduction in ruminal digestion.
Contributors
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- By Linda S. Aglio, Cyrus Ahmadi Yazdi, Syed Irfan Qasim Ali, Caryn Barnet, Jessica Bauerle, Felicity Billings, Evan Blaney, Beverly Chang, Christopher Chen, Zinaida Chepurny, Hyung Sun Choi, Allison Clark, Lauren J. Cornella, Lisa Crossley, Michael D’Ambra, Galina Davidyuk, Whitney de Luna, Manisha S. Desai, Sukumar P. Desai, Kelly G. Elterman, Michaela K. Farber, Iuliu Fat, Jaida Fitzgerald, Devon Flaherty, John A. Fox, Gyorgy Frendl, Rejean Gareau, Joseph M. Garfield, Andrea Girnius, Laverne D. Gugino, J. Tasker Gundy, Carly C. Guthrie, Lisa M. Hammond, M. Tariq Hanifi, James Hardy, Philip M. Hartigan, Thomas Hickey, Richard Hsu, Mohab Ibrahim, David Janfaza, Yuka Kiyota, Suzanne Klainer, Benjamin Kloesel, Hanjo Ko, Bhavani Kodali, Vesela Kovacheva, J. Matthew Kynes, Robert W. Lekowski, Joyce Lo, Jeffrey Lu, Alvaro A. Macias, Zahra M. Malik, Erich N. Marks, Brendan McGinn, Jonathan R. Meserve, Annette Mizuguchi, Srdjan S. Nedeljkovic, Ju-Mei Ng, Michael Nguyen, Olutoyin Okanlawon, Jennifer Oliver, Krishna Parekh, Jessica Patterson, Christian Peccora, Pete Pelletier, Sujatha Pentakota, James H. Philip, Marc Philip T. Pimentel, Timothy D. Quinn, Elizabeth M. Rickerson, Susan L. Sager, Julia Serber, Shaheen Shaikh, Stanton Shernan, David Silver, Alissa Sodickson, Pingping Song, George P. Topulos, Agnieszka Trzcinka, Richard D. Urman, Rosemary Uzomba, Joshua Vacanti, Assia Valovska, Michael Vaninetti, Scott W. Vaughan, Kamen Vlassakov, Christopher Voscopoulos, Emily L. Wang, Laura Westfall, Zhiling Xiong, Stephanie Yacoubian, Dongdong Yao, Martin Zammert, Maksim Zayaruzny, Jose Luis Zeballos, Natthasorn Zinboonyahgoon, Jie Zhou
- Edited by Linda S. Aglio, Robert W. Lekowski, Richard D. Urman
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- Book:
- Essential Clinical Anesthesia Review
- Published online:
- 05 February 2015
- Print publication:
- 08 January 2015, pp xi-xvi
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The gatekeeper residue and beyond: homologous calcium-dependent protein kinases as drug development targets for veterinarian Apicomplexa parasites
- KATELYN R. KEYLOUN, MOLLY C. REID, RYAN CHOI, YIFAN SONG, ANNA M. W. FOX, HEIDI K. HILLESLAND, ZHONGSHENG ZHANG, RAMASUBBARAO VIDADALA, ETHAN A. MERRITT, AUDREY O. T. LAU, DUSTIN J. MALY, ERKANG FAN, LYNN K. BARRETT, WESLEY C. VAN VOORHIS, KAYODE K. OJO
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- Journal:
- Parasitology / Volume 141 / Issue 11 / September 2014
- Published online by Cambridge University Press:
- 13 June 2014, pp. 1499-1509
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Specific roles of individual CDPKs vary, but in general they mediate essential biological functions necessary for parasite survival. A comparative analysis of the structure-activity relationships (SAR) of Neospora caninum, Eimeria tenella and Babesia bovis calcium-dependent protein kinases (CDPKs) together with those of Plasmodium falciparum, Cryptosporidium parvum and Toxoplasma gondii was performed by screening against 333 bumped kinase inhibitors (BKIs). Structural modelling and experimental data revealed that residues other than the gatekeeper influence compound–protein interactions resulting in distinct sensitivity profiles. We subsequently defined potential amino-acid structural influences within the ATP-binding cavity for each orthologue necessary for consideration in the development of broad-spectrum apicomplexan CDPK inhibitors. Although the BKI library was developed for specific inhibition of glycine gatekeeper CDPKs combined with low inhibition of threonine gatekeeper human SRC kinase, some library compounds exhibit activity against serine- or threonine-containing CDPKs. Divergent BKI sensitivity of CDPK homologues could be explained on the basis of differences in the size and orientation of the hydrophobic pocket and specific variation at other amino-acid positions within the ATP-binding cavity. In particular, BbCDPK4 and PfCDPK1 are sensitive to a larger fraction of compounds than EtCDPK1 despite the presence of a threonine gatekeeper in all three CDPKs.
Subtypes of major depression: latent class analysis in depressed Han Chinese women
- Y. Li, S. Aggen, S. Shi, J. Gao, Y. Li, M. Tao, K. Zhang, X. Wang, C. Gao, L. Yang, Y. Liu, K. Li, J. Shi, G. Wang, L. Liu, J. Zhang, B. Du, G. Jiang, J. Shen, Z. Zhang, W. Liang, J. Sun, J. Hu, T. Liu, X. Wang, G. Miao, H. Meng, Y. Li, C. Hu, Y. Li, G. Huang, G. Li, B. Ha, H. Deng, Q. Mei, H. Zhong, S. Gao, H. Sang, Y. Zhang, X. Fang, F. Yu, D. Yang, T. Liu, Y. Chen, X. Hong, W. Wu, G. Chen, M. Cai, Y. Song, J. Pan, J. Dong, R. Pan, W. Zhang, Z. Shen, Z. Liu, D. Gu, X. Wang, X. Liu, Q. Zhang, J. Flint, K. S. Kendler
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- Journal:
- Psychological Medicine / Volume 44 / Issue 15 / November 2014
- Published online by Cambridge University Press:
- 09 April 2014, pp. 3275-3288
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Background.
Despite substantial research, uncertainty remains about the clinical and etiological heterogeneity of major depression (MD). Can meaningful and valid subtypes be identified and would they be stable cross-culturally?
Method.Symptoms at their lifetime worst depressive episode were assessed at structured psychiatric interview in 6008 women of Han Chinese descent, age ⩾30 years, with recurrent DSM-IV MD. Latent class analysis (LCA) was performed in Mplus.
Results.Using the nine DSM-IV MD symptomatic A criteria, the 14 disaggregated DSM-IV criteria and all independently assessed depressive symptoms (n = 27), the best LCA model identified respectively three, four and six classes. A severe and non-suicidal class was seen in all solutions, as was a mild/moderate subtype. An atypical class emerged once bidirectional neurovegetative symptoms were included. The non-suicidal class demonstrated low levels of worthlessness/guilt and hopelessness. Patterns of co-morbidity, family history, personality, environmental precipitants, recurrence and body mass index (BMI) differed meaningfully across subtypes, with the atypical class standing out as particularly distinct.
Conclusions.MD is a clinically complex syndrome with several detectable subtypes with distinct clinical and demographic correlates. Three subtypes were most consistently identified in our analyses: severe, atypical and non-suicidal. Severe and atypical MD have been identified in multiple prior studies in samples of European ethnicity. Our non-suicidal subtype, with low levels of guilt and hopelessness, may represent a pathoplastic variant reflecting Chinese cultural influences.
14C Measurements of Dissolved Inorganic and Organic Carbon in Qinghai Lake and Inflowing Rivers (NE Tibet, Qinghai Plateau), China
- A J T Jull, G S Burr, W Zhou, P Cheng, S H Song, A G Leonard, L Cheng, Z S An
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- Journal:
- Radiocarbon / Volume 56 / Issue 3 / 2014
- Published online by Cambridge University Press:
- 26 July 2016, pp. 1115-1127
- Print publication:
- 2014
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There have been a number of studies that have attempted to estimate the past radiocarbon reservoir effects in Qinghai Lake, China. This article reports on measurements on modern samples collected at the lake in October 2003 and October 2009, which allow us to better understand the systematics of the lake and shed new insights on the processes occurring in the lake. The results indicate that atmospheric exchange of 14C is the main process affecting surface dissolved inorganic carbon (DIC) in the lake, but dissolved organic carbon (DOC) can be explained as a combination of sources. We also conclude that sediment carbon can be explained by a model where input from the surrounding rivers and groundwater are important, in agreement with the model of Yu et al. (2007).
QLEDs for displays and solid-state lighting
- Geoffrey J. Supran, Yasuhiro Shirasaki, Katherine W. Song, Jean-Michel Caruge, Peter T. Kazlas, Seth Coe-Sullivan, Trisha L. Andrew, Moungi G. Bawendi, Vladimir Bulović
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- Journal:
- MRS Bulletin / Volume 38 / Issue 9 / September 2013
- Published online by Cambridge University Press:
- 12 September 2013, pp. 703-711
- Print publication:
- September 2013
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The mainstream commercialization of colloidal quantum dots (QDs) for light-emitting applications has begun: Sony televisions emitting QD-enhanced colors are now on sale. The bright and uniquely size-tunable colors of solution-processable semiconducting QDs highlight the potential of electroluminescent QD light-emitting devices (QLEDs) for use in energy-efficient, high-color-quality thin-film display and solid-state lighting applications. Indeed, this year’s report of record-efficiency electrically driven QLEDs rivaling the most efficient molecular organic LEDs, together with the emergence of full-color QLED displays, foreshadow QD technologies that will transcend the optically excited QD-enhanced products already available. In this article, we discuss the key advantages of using QDs as luminophores in LEDs and outline the 19-year evolution of four types of QLEDs that have seen efficiencies rise from less than 0.01% to 18%. With an emphasis on the latest advances, we identify the key scientific and technological challenges facing the commercialization of QLEDs. A quantitative analysis, based on published small-scale synthetic procedures, allows us to estimate the material costs of QDs typical in light-emitting applications when produced in large quantities and to assess their commercial viability.
The structure of the symptoms of major depression: exploratory and confirmatory factor analysis in depressed Han Chinese women
- Y. Li, S. Aggen, S. Shi, J. Gao, Y. Li, M. Tao, K. Zhang, X. Wang, C. Gao, L. Yang, Y. Liu, K. Li, J. Shi, G. Wang, L. Liu, J. Zhang, B. Du, G. Jiang, J. Shen, Z. Zhang, W. Liang, J. Sun, J. Hu, T. Liu, X. Wang, G. Miao, H. Meng, Y. Li, C. Hu, Y. Li, G. Huang, G. Li, B. Ha, H. Deng, Q. Mei, H. Zhong, S. Gao, H. Sang, Y. Zhang, X. Fang, F. Yu, D. Yang, T. Liu, Y. Chen, X. Hong, W. Wu, G. Chen, M. Cai, Y. Song, J. Pan, J. Dong, R. Pan, W. Zhang, Z. Shen, Z. Liu, D. Gu, X. Wang, X. Liu, Q. Zhang, J. Flint, K. S. Kendler
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- Journal:
- Psychological Medicine / Volume 44 / Issue 7 / May 2014
- Published online by Cambridge University Press:
- 07 August 2013, pp. 1391-1401
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Background
The symptoms of major depression (MD) are clinically diverse. Do they form coherent factors that might clarify the underlying nature of this important psychiatric syndrome?
MethodSymptoms at lifetime worst depressive episode were assessed at structured psychiatric interview in 6008 women of Han Chinese descent, age ⩾30 years with recurrent DSM-IV MD. Exploratory factor analysis (EFA) and confirmatoryfactor analysis (CFA) were performed in Mplus in random split-half samples.
ResultsThe preliminary EFA results were consistently supported by the findings from CFA. Analyses of the nine DSM-IV MD symptomatic A criteria revealed two factors loading on: (i) general depressive symptoms; and (ii) guilt/suicidal ideation. Examining 14 disaggregated DSM-IV criteria revealed three factors reflecting: (i) weight/appetite disturbance; (ii) general depressive symptoms; and (iii) sleep disturbance. Using all symptoms (n = 27), we identified five factors that reflected: (i) weight/appetite symptoms; (ii) general retarded depressive symptoms; (iii) atypical vegetative symptoms; (iv) suicidality/hopelessness; and (v) symptoms of agitation and anxiety.
ConclusionsMD is a clinically complex syndrome with several underlying correlated symptom dimensions. In addition to a general depressive symptom factor, a complete picture must include factors reflecting typical/atypical vegetative symptoms, cognitive symptoms (hopelessness/suicidal ideation), and an agitated symptom factor characterized by anxiety, guilt, helplessness and irritability. Prior cross-cultural studies, factor analyses of MD in Western populations and empirical findings in this sample showing risk factor profiles similar to those seen in Western populations suggest that our results are likely to be broadly representative of the human depressive syndrome.
Quantitative Energy Dispersive Analysis Technique of SiGe at Site-specific area using In-situ Lift-out TEM sample
- T.-S. Park, H.-J. Kang, J.-W. Chung, B.-M. Song, T.-S. Back, H.-J. Kim, C.-R. Kim
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- Journal:
- Microscopy and Microanalysis / Volume 19 / Issue S2 / August 2013
- Published online by Cambridge University Press:
- 09 October 2013, pp. 1286-1287
- Print publication:
- August 2013
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Extended abstract of a paper presented at Microscopy and Microanalysis 2013 in Indianapolis, Indiana, USA, August 4 – August 8, 2013.
Plasma 25-hydroxyvitamin D3, folate and vitamin B12 biomarkers among international colorectal cancer patients: a pilot study
- Cornelia M. Ulrich, Adetunji T. Toriola, Erin M. Siegel, Hermann Brenner, Jenny Chang-Claude, Clare Abbenhardt, Jana Kotzmann, Xiaoling Song, Robert W. Owen, Michael Hoffmeister, Heiko Becher, David Shibata, Kathy Vickers, Shannon K. Rush, Karen Makar, Gerd Würtele, Roswitha Haubner, Thomas A. Sellers, William Grady
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- Journal:
- Journal of Nutritional Science / Volume 2 / 2013
- Published online by Cambridge University Press:
- 09 April 2013, e9
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Vitamin D and folate are associated with decreased colorectal cancer risk and their association with colorectal cancer prognosis is under investigation. We assessed the levels of plasma 25-hydroxyvitamin D3 (25(OH)D3), folate and vitamin B12 in an international pilot study in order to determine variability of these biomarkers based on geographical location. Plasma 25(OH)D3, folate and vitamin B12 concentrations were measured in 149 invasive, newly diagnosed colorectal cancer cases from Heidelberg (Germany), Seattle (WA, USA), and Tampa (FL, USA) and in ninety-one age- and sex-matched controls. Their associations with potential predictors were assessed using multivariate linear regression analyses. Plasma 25(OH)D3, folate and vitamin B12 concentrations differed by location. Other predictors were season for 25(OH)D3 and tumour stage (vitamin B12). Season-corrected average 25(OH)D3 concentrations were higher in Heidelberg (31·7 ng/ml; range 11·0–83·0 ng/ml) than in Seattle (23·3 ng/ml; range 4·0–80·0 ng/ml) and Tampa (21·1 ng/ml; range 4·6–51·6 ng/ml). In Heidelberg, a strong seasonal variation was observed. Folate (11·1 ng/ml) and vitamin B12 (395 pg/ml) concentrations in Heidelberg were lower than those in Seattle (25·3 ng/ml and 740 pg/ml, respectively) and Tampa (23·8 ng/ml and 522 pg/ml, respectively). Differences in plasma 25(OH)D3 and folate concentrations between Heidelberg and the US sites were observed, probably reflecting variation in outdoor activities and sun-avoidance behaviour during summer as well as in folic acid fortification and supplement use. Intra-site differences at each study location were greater than between-location variability, suggesting that individual health behaviours play a significant role. Nevertheless, the intra-site differences we observed may be due to chance because of the limited sample size. Our pilot study illustrates the value of an international cohort in studying colorectal cancer prognosis to discern geographical differences in a broad range of exposures.
Synthesis and structure of the ternary nitride Li6WN4
- W. X. Yuan, J. W. Hu, Y. T. Song, W. J. Wang, Y. P. Xu
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- Journal:
- Powder Diffraction / Volume 20 / Issue 1 / March 2005
- Published online by Cambridge University Press:
- 01 March 2012, pp. 18-21
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The ternary nitridotungstate Li6WN4 has been synthesized via the solid state reaction of lithium subnitride, Li3N, with W under nitrogen. High quality X-ray powder diffraction data were collected for the crystal-structure determination. Li6WN4 crystallizes in the tetragonal system, space group P42∕nmc, with cell parameters a=6.6759(3) Å and c=4.9280(3) Å, Z=2. Preliminary thermal stability measurements of Li6WN4 show that it is sensitive to moisture, even at room temperature, and decomposes at high temperatures below 1000 °C under flowing nitrogen.
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- By Rose Teteki Abbey, K. C. Abraham, David Tuesday Adamo, LeRoy H. Aden, Efrain Agosto, Victor Aguilan, Gillian T. W. Ahlgren, Charanjit Kaur AjitSingh, Dorothy B E A Akoto, Giuseppe Alberigo, Daniel E. Albrecht, Ruth Albrecht, Daniel O. Aleshire, Urs Altermatt, Anand Amaladass, Michael Amaladoss, James N. Amanze, Lesley G. Anderson, Thomas C. Anderson, Victor Anderson, Hope S. Antone, María Pilar Aquino, Paula Arai, Victorio Araya Guillén, S. Wesley Ariarajah, Ellen T. Armour, Brett Gregory Armstrong, Atsuhiro Asano, Naim Stifan Ateek, Mahmoud Ayoub, John Alembillah Azumah, Mercedes L. García Bachmann, Irena Backus, J. Wayne Baker, Mieke Bal, Lewis V. Baldwin, William Barbieri, António Barbosa da Silva, David Basinger, Bolaji Olukemi Bateye, Oswald Bayer, Daniel H. Bays, Rosalie Beck, Nancy Elizabeth Bedford, Guy-Thomas Bedouelle, Chorbishop Seely Beggiani, Wolfgang Behringer, Christopher M. Bellitto, Byard Bennett, Harold V. Bennett, Teresa Berger, Miguel A. Bernad, Henley Bernard, Alan E. Bernstein, Jon L. Berquist, Johannes Beutler, Ana María Bidegain, Matthew P. Binkewicz, Jennifer Bird, Joseph Blenkinsopp, Dmytro Bondarenko, Paulo Bonfatti, Riet en Pim Bons-Storm, Jessica A. Boon, Marcus J. Borg, Mark Bosco, Peter C. Bouteneff, François Bovon, William D. Bowman, Paul S. Boyer, David Brakke, Richard E. Brantley, Marcus Braybrooke, Ian Breward, Ênio José da Costa Brito, Jewel Spears Brooker, Johannes Brosseder, Nicholas Canfield Read Brown, Robert F. Brown, Pamela K. Brubaker, Walter Brueggemann, Bishop Colin O. Buchanan, Stanley M. Burgess, Amy Nelson Burnett, J. Patout Burns, David B. Burrell, David Buttrick, James P. Byrd, Lavinia Byrne, Gerado Caetano, Marcos Caldas, Alkiviadis Calivas, William J. Callahan, Salvatore Calomino, Euan K. Cameron, William S. Campbell, Marcelo Ayres Camurça, Daniel F. Caner, Paul E. Capetz, Carlos F. Cardoza-Orlandi, Patrick W. Carey, Barbara Carvill, Hal Cauthron, Subhadra Mitra Channa, Mark D. 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Deichmann Edwards, Miguel A. De La Torre, George E. Demacopoulos, Thomas de Mayo, Leah DeVun, Beatriz de Vasconcellos Dias, Dennis C. Dickerson, John M. Dillon, Luis Miguel Donatello, Igor Dorfmann-Lazarev, Susanna Drake, Jonathan A. Draper, N. Dreher Martin, Otto Dreydoppel, Angelyn Dries, A. J. Droge, Francis X. D'Sa, Marilyn Dunn, Nicole Wilkinson Duran, Rifaat Ebied, Mark J. Edwards, William H. Edwards, Leonard H. Ehrlich, Nancy L. Eiesland, Martin Elbel, J. Harold Ellens, Stephen Ellingson, Marvin M. Ellison, Robert Ellsberg, Jean Bethke Elshtain, Eldon Jay Epp, Peter C. Erb, Tassilo Erhardt, Maria Erling, Noel Leo Erskine, Gillian R. Evans, Virginia Fabella, Michael A. Fahey, Edward Farley, Margaret A. Farley, Wendy Farley, Robert Fastiggi, Seena Fazel, Duncan S. Ferguson, Helwar Figueroa, Paul Corby Finney, Kyriaki Karidoyanes FitzGerald, Thomas E. FitzGerald, John R. Fitzmier, Marie Therese Flanagan, Sabina Flanagan, Claude Flipo, Ronald B. Flowers, Carole Fontaine, David Ford, Mary Ford, Stephanie A. Ford, Jim Forest, William Franke, Robert M. Franklin, Ruth Franzén, Edward H. Friedman, Samuel Frouisou, Lorelei F. Fuchs, Jojo M. Fung, Inger Furseth, Richard R. Gaillardetz, Brandon Gallaher, China Galland, Mark Galli, Ismael García, Tharscisse Gatwa, Jean-Marie Gaudeul, Luis María Gavilanes del Castillo, Pavel L. Gavrilyuk, Volney P. Gay, Metropolitan Athanasios Geevargis, Kondothra M. George, Mary Gerhart, Simon Gikandi, Maurice Gilbert, Michael J. Gillgannon, Verónica Giménez Beliveau, Terryl Givens, Beth Glazier-McDonald, Philip Gleason, Menghun Goh, Brian Golding, Bishop Hilario M. Gomez, Michelle A. Gonzalez, Donald K. Gorrell, Roy Gottfried, Tamara Grdzelidze, Joel B. Green, Niels Henrik Gregersen, Cristina Grenholm, Herbert Griffiths, Eric W. Gritsch, Erich S. Gruen, Christoffer H. Grundmann, Paul H. Gundani, Jon P. Gunnemann, Petre Guran, Vidar L. Haanes, Jeremiah M. 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Yee, Viktor Yelensky, Yeo Khiok-Khng, Gustav K. K. Yeung, Angela Yiu, Amos Yong, Yong Ting Jin, You Bin, Youhanna Nessim Youssef, Eliana Yunes, Robert Michael Zaller, Valarie H. Ziegler, Barbara Brown Zikmund, Joyce Ann Zimmerman, Aurora Zlotnik, Zhuo Xinping
- Edited by Daniel Patte, Vanderbilt University, Tennessee
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- The Cambridge Dictionary of Christianity
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- 05 August 2012
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- 20 September 2010, pp xi-xliv
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Surveillance of antimicrobial resistance of Salmonella enterica serotype Typhi in seven Asian countries
- C.-H. CHUANG, L.-H. SU, J. PERERA, C. CARLOS, B. H. TAN, G. KUMARASINGHE, T. SO, P. H. VAN, A. CHONGTHALEONG, P.-R. HSUEH, J.-W. LIU, J.-H. SONG, C.-H. CHIU
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- Journal:
- Epidemiology & Infection / Volume 137 / Issue 2 / February 2009
- Published online by Cambridge University Press:
- 12 May 2008, pp. 266-269
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Two hundred and four Salmonella enterica serotype Typhi (S. Typhi) isolates were collected from seven Asian countries during 2002–2004. Multidrug-resistant S. Typhi (resistant to ⩾3 antibiotics) was detected in 84 (41·2%) isolates and 142 (69·6%) showed reduced susceptibility to ciprofloxacin (minimum inhibitory concentration=0·125–1·0 mg/l). This study highlights the worsening situation of antimicrobial resistance of S. Typhi in Asia.
Evaluation of genetic diversity of Chinese native geese revealed by microsatellite markers
- H.-F. LI, K.-W. CHEN, N. YANG, W.-T. SONG, Q.-P. TANG
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- Journal:
- World's Poultry Science Journal / Volume 63 / Issue 3 / September 2007
- Published online by Cambridge University Press:
- 21 September 2007, pp. 381-390
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- September 2007
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China has an abundant and a wide variety of goose resources. The systemic estimation of genetic diversity of Chinese indigenous geese will provide an important scientific basis for the conservation and utilization of the resource. Twenty-six Chinese native goose populations were studied to estimate genetic diversity and genetic structure using 31-microsatellite markers. The genetic relationships between populations were analyzed in combination with their geographic distribution and origin of these breeds. According to the allele frequencies of 31-microsatellite loci, polymorphic information content (PIC), average heterozygosity (H) and DA genetic distances were calculated. Twenty-nine of the 31 microsatellite loci were medium or high polymorphism, so the 29 microsatellite markers were effective markers for analysis of genetic relationship among goose breeds. The average expected heterozygosity (HE) was between 0.501 and 0.705, the numeric order of which was consistent with that of PIC, and which reflected the strong genetic potential and strong adaptability. The topology of phylogenetic tree constructed from a Neighbour- Joining method based on DA genetic distances, showed general patterns of relationship and genetic structure among the populations studied. Topology analysis revealed that the twenty-six Chinese populations were divided into five groups and that the genetic relationships among the populations had obvious association with their historical relations and geographical distribution.